Transmembrane TNF- : structure, function and interaction with anti-TNF agents
نویسندگان
چکیده
منابع مشابه
Transmembrane TNF-α: structure, function and interaction with anti-TNF agents
Transmembrane TNF-alpha, a precursor of the soluble form of TNF-alpha, is expressed on activated macrophages and lymphocytes as well as other cell types. After processing by TNF-alpha-converting enzyme (TACE), the soluble form of TNF-alpha is cleaved from transmembrane TNF-alpha and mediates its biological activities through binding to Types 1 and 2 TNF receptors (TNF-R1 and -R2) of remote tiss...
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TNF-α (TNF), a pro-inflammatory cytokine is synthesized as a 26 kDa protein, anchors in the plasma membrane as transmembrane TNF (TmTNF), and is subjected to proteolysis by the TNF-α converting enzyme (TACE) to release the 15 kDa form of soluble TNF (sTNF). TmTNF and sTNF interact with 2 distinct receptors, TNF-R1 (p55) and TNF-R2 (p75), to mediate the multiple biologic effects of TNF described...
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ژورنال
عنوان ژورنال: Rheumatology
سال: 2010
ISSN: 1462-0324,1462-0332
DOI: 10.1093/rheumatology/keq031